Saturday, February 7, 2015

ABO-Incompatible Kidney Transplantation Is a Novel Risk Factor for BK Nephropathy

A link between ABO-incompatible kidney transplantation and the risk of BK virus allograft nephropathy (BKVAN) has been identified in a report from Johns Hopkins Hospital.1 The 11 (17.7%) of 62 cases of BKVAN were identified by protocol (n = 5) or indication (n = 6) biopsies. The incidence of BKVAN in HLA–incompatible allograft recipients (transplantation after the removal of donor-specific HLA antibodies) and compatible allograft recipients was 5.9% and 3.0%, respectively. In a multivariable analysis, ABO-incompatible kidney transplantation was identified as an independent risk factor for the development of BKVAN (read more)
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