Postoperative Rebound of Anti-Blood Type Antibodies and Antibody-Mediated Rejection after ABO-Incompatible Living Related Kidney Transplantation.

The purpose of this study is to examine whether postoperative anti-blood type antibody rebound is attributed to kidney allograft rejection in ABO blood type-incompatible (ABO-I) living related kidney transplantation (KTx). A total of 191 ABO-I recipients who received ABO-I living related KTx between 2001 and 2013 were divided into two groups: Group 1 consisted of low rebound (≦1:32), N=170, and Group 2 of high rebound (≧1:64), N=21, according to the levels of the rebounded anti-blood type antibodies within one year after transplantation. No prophylactic treatment for rejection was administered for elevated anti-blood type antibodies, regardless of the levels of the rebounded antibodies. Within one year after transplantation, T cell-mediated rejection was observed in 13 of 170 recipients (13/170, 8%) in Group 1, and in 2 of 21 recipients (2/21, 10%) in Group 2 (Groups 1 vs. 2, P=0.432). Antibody-mediated rejection was observed in 15 of 170 recipients (15/170, 9%) and 2 of 21 recipients (2/21, 10%) in Groups 1 and 2, respectively (P=0.898). In this study, we found no correlation between the postoperative anti-blood type antibody rebound and the incidence of acute rejection. We concluded that no treatment is necessary for rebounded anti-blood type antibodies (read more) Print this post