Wednesday, April 2, 2014

Immunosuppressants and alloimmunization against red blood cell transfusions

Background : Patients receiving red blood cell (RBC) transfusions are at risk of developing alloantibodies against donor RBC antigens. The risk of alloimmunization is dependent on the number of units administered and patient's genetic predisposition, but has also been suggested to be modulated by a patient's clinical profile. Our aim was to examine whether immunosuppressants suppress the development of clinically relevant RBC antibodies.
Study Design and Methods : A two-center case-referent study was performed where case patients and control patients were sampled from all consecutive patients (17,750 patients) who had received their first and subsequent RBC transfusions in a 5-year period in the study centers. Cases were all patients with a first detected RBC alloantibody preceded by negative antibody screens. Control patients were two-to-one matched to the case patients on the number of RBC transfusions. Logistic regression analysis was used to examine the association between immunosuppressant exposure and the subsequent occurrence of RBC alloimmunization.
Results : A total of 156 case patients and 312 control patients in the study received a median of six transfusions (interquartile range, 3-11). Among the total study population, 207 patients received immunosuppressive therapy, with 142 patients receiving only corticosteroids, four receiving only other immunosuppressants, and 61 receiving both. The incidence of alloimmunization among patients using immunosuppressants was lower than among other patients receiving RBCs (adjusted relative rate, 0.55; 95% confidence interval, 0.34-0.91).
Conclusion : Our findings support a considerably lower risk of alloimmunization with the use of immunosuppressive medications (read more) Print this post

1 comment:

  1. I'M TOTALLY FREE FROM HEPATITIS B. FOR OVER YEARS LIVING WITH  IT
     I’m Stephenie Brown, i was diagnosed with Hepatitis B 3 years ago, i lived in pain with the knowledge that i wasn’t going to ever be well again i contacted so many herbal doctors about herbs to cure me and ended up spending some amount of money but i never got better i was determined to get my lifestyle back and to be able to do things am restricted from doing so one day i saw a lady’s post on how Herbalist Dr. JAMES cured her  from Hiv virus with his herbal medicine. I contacted the same Doctor through his email....drjamesherbalmix@gmail.com....we spoke, i told him all that i was going through and he told me not to worry that everything will be more better again so he prepared a herbal medicine and send it to me through DHL courier company and told me the dosage,after 13 days of completing the herbal medicine,i was totally free from Hepatitis,so I went to see a doctor for a blood test ,After taking a sample of my blood for the test the result came out negative,i just can’t deny that i’m the most happiest woman on earth this very moment ,i’m so happy and thanks to Herbalist Doctor JAMES
    He also told me he cures  diseases   such as Melanoma ,Cancer,Weak Erection,Wart Remover,Hpv,Herpes,Fibromyalgia,Hiv,Hepatitis b,Liver/Kidney Inflammatory,Epilepsy,Infertility,Fibroid,Diabetes,Dercum,Copd,Back pain,Nephrotic syndrome,
     AND MORE contact him  on
    Email..... DRJAMESHERBALMIX@GMAIL.COM

    ReplyDelete